When implantation fails repeatedly or miscarriages occur despite good-quality embryos, an over-active immune response—particularly raised natural-killer (NK) cell activity—may be part of the problem.
Intravenous Intralipid® infusions are a safe, well-studied option to calm these immune pathways and give the embryo the best chance to implant and thrive.
Sterile 20% fat emulsion containing soya-bean oil, egg-yolk phospholipids, glycerol and water
Delivers anti-inflammatory omega-6/omega-9 fatty acids that modulate cytokines and NK-cell activity
Originally developed for parenteral nutrition with over 40 years of safe clinical use
When infused slowly, Intralipid temporarily modulates cytokines and NK-cell cytotoxicity without suppressing the wider immune system, creating an optimal environment for embryo implantation.
Evidence reviews suggest higher ongoing-pregnancy and live-birth rates in selected women with recurrent implantation failure (RIF) or miscarriage when Intralipid is added to IVF cycles.
Reduces the chance that the embryo will be treated as a “foreign body.”
Healthy endometrial perfusion supports implantation.
Helps sustain early placental development (e.g. TNF-α).
A fraction of the price of immunoglobulin therapy yet comparable mechanistic benefits.
Clinical studies demonstrate improved pregnancy outcomes when Intralipid therapy is integrated into fertility treatment protocols for women with immune-related implantation challenges.
(A full consultant-led assessment determines suitability.)
Rule out contraindications such as soy/egg allergy or lipid metabolism disorders.
250 ml over 90 minutes, usually 7–10 days before embryo transfer (or immediately after a positive pregnancy test in natural conception).
Repeated at 6–8 weeks’ gestation if NK-cell activity remains raised.
Nurse observations during infusion; follow-up call 24 h later.
Free to talk now? One of our friendly ZEN advisors will contact you to answer any questions straight away and to arrange your consultation, or you can choose a time for a call back later.
Get answers to common questions about Intralipid IV therapy
No. Vitamin drips deliver micronutrients, whereas Intralipid is a fat emulsion designed to modulate immune pathways relevant to fertility.
Sadly, no therapy can promise success; Intralipid simply stacks the odds in your favour when immune factors are involved.
Yes. There is no sedation and the infusion does not impair alertness.
Each infusion takes approximately 90 minutes, plus consultation time. You can relax, work, or use our Wi-Fi during the treatment.
Typically, patients receive an initial infusion 7-10 days before embryo transfer, with a potential top-up at 6-8 weeks’ gestation if needed.
The information above is for educational purposes and does not replace personalised medical advice. Always consult a qualified fertility specialist before starting any new treatment.
Cryotherapy